Calcium oscillations-coupled conversion of actin travelling waves to standing oscillations

by Wu M, Wu X, De Camilli P

Proc Natl Acad Sci USA  2013 Jan 22;110(4):1339-44

Dynamic spatial patterns of signaling factors or macromolecular assemblies in the form of oscillations or traveling waves have emerged as important themes in cell physiology. Feedback mechanisms underlying these processes and their modulation by signaling events and reciprocal cross-talks remain poorly understood. In this work we show that antigen stimulation of mast cells triggers cyclic recruitment of curvature-generating protein FBP17 and actin regulatory factors that can be manifested in either spatial pattern. Further mechanistic studies revealed an unexpected pattern-rendering mechanism.

Read online: PNAS.

Learn more about Wu Min’s research.