CBIS Principal Investigators
Cynthia He | Associate Professor of Biological Sciences, Singapore National Research Foundation (NRF) Fellow. Cell and molecular biology of parasitic pathogens, cell cycle regulation, and organelle biogenesis. More →
Sheemei Lok | Professor of Biological Sciences, Duke/NUS Medical School, Singapore National Research Foundation (NRF) Fellow. Understanding the pathology of dengue virus infection and the mechanism of neutralization by antibodies and other molecules. More →
Lu Gan | Associate Professor of Biological Sciences. Electron cryotomographic analysis of picoplankton, spindles in other single-celled eukaryotes, and applications of electron tomography to cell biology. More →
Paul Matsudaira, Director | Professor, Department of Biological Sciences, Professor of Biomedical Engineering, Professor , Mechanobiology Institute, Singapore (MBI). Mechanobiology of cells and tissues, dynamics of nano-scale water, bioimaging sciences. More →
Yan Jie | Professor of Physics, Mechanobiology Institute, Singapore (MBI). Interactions of proteins with DNA and resulting folding and organization of DNA in the genomes of viruses, bacteria, and cells. More →
Zhao Ziqing (Winston) | Assistant Professor, Department of Chemistry (NUS Presidential Young Professorship). Development and application of single-cell optical imaging approaches to quantitatively probe the biophysics of chromatin dynamics inside mammalian cell nucleus. More →
CBIS Affiliate Members
George Barbastathis | Professor of Mechanical Engineering, MIT, SMART. Professor Barbastathis is a world renowned expert in optics with a particular emphasis on methods for imaging and reconstructing volumes. In Singapore his lab is developing holographic confocal methods for imaging intact tissues.
Wah Chiu | Professor of Biochemistry, Baylor College of Medicine, Director, NIH National Center for Macromolecular Imaging, Visiting Professor, Department of Biological Sciences, NUS, and Visiting Investigator, Mechanobiology Institute, Singapore (MBI). The Chu lab is a world-leader in the determination of complex macromolecular structures, particularly viruses, by cryoelectron microscopy, and the development of advanced computational methods for cryoEM image processing, analysis, and modeling.
Patrice Koehl | Professor of Computer Science, University of California at Davis, Associate Director of Bioinformatics, UC Davis Genome Center. Professor Koehl is a computational physicist who studies the role of shapes on the folding of proteins.
Matt Lang | Professor of Chemical and Biomolecular Engineering, Vanderbilt University, SMART. Professor Lang measures and correlates chemical and mechanical transitions with very precise and accurate force-spectroscopy instruments based on optical traps. His lab is characterizing the mechanochemical steps in kinesin motility, the processing of proteins by the ClpX ATPase, and the structural transitions in the actin cytoskeleton.
Peter So | Professor of Mechanical Engineering and Biological Engineering, MIT, SMART. The So Lab has pioneered the development of optical microscopes from a two-photon slice and view for characterizing organs and tissues to super-resolution methods for describing the organization of macromolecules in cells.