Duane Loh

Biography

2016-current: Assistant professor at the departments of Physics and Biological Sciences at NUS.

2013-2016: Lee Kuan Yew Postdoctoral Fellowship award at NUS.

2010-2010: Research fellow at SLAC National Accelerator Laboratory (Menlo Park, CA, USA).

2004-2010: Ph.D. in theoretical Physics at Cornell University (Ithaca, NY, USA).

2000-2004: B.Sc. in Physics at Harvey Mudd College (Claremont, CA, USA).

Research

Since his time at Cornell, Duane has been developing algorithms to probe nanoscale phenomena by examining their signatures, which are hidden in noisy, incomplete and heterogeneous X-ray diffractive datasets.

duaneLoh_structuralComplexitySM
Structural complexity in aerosol soot: Scale-invariant random processes drive the growth and aggregation of these aerosols, which results in fractal-like geometrical properties.

These algorithms were applied during his postdoctoral appointment at SLAC National Accelerator Laboratory to investigate airborne aerosols, tiny viruses, paramagnetic aggregates, and supercooled water using X-ray free-electron lasers.

At NUS, Duane explores the physical, statistical and biological challenges encountered in electron microscopy and x-ray diffractive imaging to understand how we can extend our study and manipulation of mesoscale structure and dynamics.

Selected Publications

Duane Loh, N., Soumyo Sen, Michel Bosman, Shu Fen Tan, Jun Zhong, Christian A. Nijhuis, Petr Král, Paul Matsudaira, and Utkur Mirsaidov. 2016. “Multistep Nucleation of Nanocrystals in Aqueous Solution.” Nature Chemistry 9 (1). Nature Research: 77–82.

Ayyer, Kartik, Ti-Yen Lan, Veit Elser, and N. Duane Loh. 2016. “Dragonfly: An Implementation of the Expand-Maximize-Compress Algorithm for Single-Particle Imaging.” Journal of Applied Crystallography 49 (Pt 4): 1320–35.

Loh, N. Duane. 2014. “A Minimal View of Single-Particle Imaging with X-Ray Lasers.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 369 (1647): 20130328.

Sellberg, J. A., C. Huang, T. A. McQueen, N. D. Loh, H. Laksmono, D. Schlesinger, R. G. Sierra, et al. 2014. “Ultrafast X-Ray Probing of Water Structure below the Homogeneous Ice Nucleation Temperature.” Nature 510 (7505): 381–84.

Loh, N. Duane, Dmitri Starodub, Lukas Lomb, Christina Y. Hampton, Andrew V. Martin, Raymond G. Sierra, Anton Barty, et al. 2013. “Sensing the Wavefront of X-Ray Free-Electron Lasers Using Aerosol Spheres.” Optics Express 21 (10): 12385–94.

Loh, N. D., C. Y. Hampton, A. V. Martin, D. Starodub, R. G. Sierra, A. Barty, A. Aquila, et al. 2012. “Fractal Morphology, Imaging and Mass Spectrometry of Single Aerosol Particles in Flight.” Nature 486 (7404): 513–17.

Loh, N. D., M. J. Bogan, V. Elser, A. Barty, S. Boutet, S. Bajt, J. Hajdu, et al. 2010. “Cryptotomography: Reconstructing 3D Fourier Intensities from Randomly Oriented Single-Shot Diffraction Patterns.” Physical Review Letters 104 (22): 225501.

Loh, Ne-Te Duane, and Veit Elser. 2009. “Reconstruction Algorithm for Single-Particle Diffraction Imaging Experiments.” Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics 80 (2 Pt 2): 026705.