Dipanjan Bhattacharya

Research Interests

  • Development of DSLM microscopy
  • Development of Volume-Holographic microscopy
  • Development of Optical Tweezer
  • 3D imaging and Image processing
  • Image-segmentation for Electron microscopy
  • Biophysics tissue-mechanics
  • Fluorescent spectroscopic methods
  • FCS, FRAP, Anisotropy
  • High throughput screening
  • Automation and instrumentation

Selected Publications

Nanoparticle Dynamics in a Nanodroplet. Jingyu Lu, Zainul Aabdin, N Duane Loh, Dipanjan Bhattacharya, and Utkur Mirsaidov. Nano Lett., 2014, 14 (4), pp 2111–2115 (DOI: 10.1021/nl500766j).

Direct observation of the stick-slip movement of nm-size water droplets. U. Mirsaidov, H. Zheng, D. Bhattacharya, Y. Casana, P. Matsudaira. In press: Proc. Natl. Acad. Sci. U.S.A. 2012.

dipanjanPNAS
Dynamics of a moving nanodroplet from Direct observation of stick-slip movements of water nanodroplets induced by an electron beam, PNAS.

Improving signal-to-noise ratio of structured light microscopy based on photon reassignment. VR Singh, H. Choi, EYS. Yew, D. Bhattacharya, L. Yuan, CJ R. Sheppard, JC. Rajapakse, G. Barbastathis, PTC.So. Biomed Opt Express. (2012); 3(1): 206-14.

Rankl-induced osteoclastogenesis leads to loss of mineralization in a medaka osteoporosis model. TT. To, PE Witten, J Renn, D Bhattacharya, A. Huysseune and C. Winkler. Development. (2012); 139(1): 141-50.

Dynamic organization of chromatin assembly & transcription factories in living cells. B Sinha, D. Bhattacharya, DK Sinha, S Talwar, S Maharana, S Gupta, GV. Shivashankar, Methods in Cell Biology, (Elsevier Press). (2010) 98, 57-78. (Book chapter)

Spatio-temporal plasticity in chromatin organization in mouse cell differentiation & during Drosophila embryogenesis. D. Bhattacharya, S Talwar, A Mazumder, G.V.Shivashankar. Biophysical Journal (2009). 96, 3832-3839.

Trichostatin-A induces differential changes in histone protein dynamics and expression in HeLa cells. J Rao, D. Bhattacharya, B Banerjee, A Sarin &

Chromatin Structure Exhibits Spatio-Temporal Heterogeneity within the Cell Nucleus. B Banerjee, D. Bhattacharya, and G.V. Shivashankar. Biophysical Journal. (2006). 91: 2297–2303. (Cover Page of Biophysical  journal)

EGFP-Tagged Core and Linker Histones Diffuse via Distinct Mechanisms within Living Cells. D. Bhattacharya, A Mazumder, S. A Miriam, and G. V. Shivashankar. Biophysical Journal. (2006). 91: 2326–2336.

Development of single molecule tracking confocal fluorescence microscope for gene expression analysis. D Sinha, D. Bhattacharya, B Banerjee, F Meeran & G.V.Shivashankar. Current Science (2004). 87, 239-244.

Bhattacharya's custom microscope at CBIS labs.
Bhattacharya’s custom microscope at CBIS labs.

Selected Conference Talks

Probing the dynamics of nucleosomes within single live cells. 49th Annual Meeting of the Biophysical Society, Long Beach, California, USA., Feb 12-16, 2005.

Development of HiLo Based DSLM to understand tissue migration in different developmental context in fish model system. Third Light Sheet Microscopy conference, Toulouse, France. (October- 2011).

3D invivo imaging to understand how the intestinal epithelium migrates. EMBO practical course on the F-techniques in Cell and Developmental Biology, Singapore. 2009.

Development of HiLo based DSLM to understand tissue migration of neurulation. Focus on Microscopy Conference (FOM-12), April-2012. Singapore.