CBIS Visiting Scientist: Dr Frank Holsteyns 26-29 APR 2016

CBIS is pleased to welcome Dr Frank Holsteyns, from IMEC, Belgium (hosted by Dr Utkur Mirsaidov) who will be arriving in Singapore on 26 April 2016 and will be with us until 29 April 2016.

He will be located in CBIS office in room #02-15. His email is Frank.Holsteyns@imec.be.

Dr Holsteyns will be sharing about Wet process challenges for sub-10 nm technology nodes in semiconductor processing in his seminar on 28 April at 4pm in Seminar Room (S1-02-17). All are welcome to attend.

Recruiting research assistant in statistical optics

Fast electron detectors are rapidly changing electron microscopy. These detectors allow probabilistic imaging of very many noisy, incomplete, chance observations that are then statistically classified and interpreted. This mode of imaging has enabled unprecedented high resolution imaging of dynamical and heterogeneous systems.

The Centre for BioImaging Sciences at the National University of Singapore is one of the few places in the world that develops new algorithmic approaches in such probabilistic electron microscopy. We are looking for motivated, aspiring scientists who would like to join us in developing this emerging field of statistical electron microscopy.

CBIS PI Shee Mei Lok awarded National Research Foundation Investigatorship

Assistant Professor Lok is one of the recipients of the prestigious National Research Foundation Investigatorship.

Dengue Virus (DENV) infects approximately 100 million people each year. Increased travel, together with global climate change will result in further geographical expansion of the territory of the dengue mosquito vector, Aedes aegypti. There is an urgent need to develop safe and effective dengue therapeutics and vaccine.

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CBIS PI Shee Mei Lok at the Titan Krios at the National University of Singapore Centre for BioImaging Research

In vitro experiments have shown that non-neutralizing antibodies can enhance DENV infection of Fc receptor bearing macrophages, one of the natural host cells for the virus. This suggested that the presence of non-neutralizing epitopes in a vaccine could potentially increase the chances that a person who had received the vaccine would develop the severe form of the disease, dengue hemorrhagic fever. For this reason, a more promising approach for engineering an effective DENV vaccine is to focus on including neutralizing epitopes. Thus, mapping of neutralizing epitopes is a necessary component of DENV vaccine research. Furthermore, understanding the neutralization mechanism of antibodies and the entry of DENV into the host cells also could aid in the design of targeted therapeutics.

The research in her laboratory therefore, focuses on the understanding of the pathology of dengue virus infection and the mechanism of neutralization by antibodies and other molecules so as to facilitate the development of suitable vaccines and therapeutics. A combination of molecular, immunological, biochemical and structural techniques (x ray crystallography and cryoEM image reconstruction techniques) will be used to achieve these aims.

Read more about Associate Professor Lok’s research.